Part II: new frontiers in antibacterial drug discovery
نویسندگان
چکیده
منابع مشابه
New frontiers in cardiology: drug-eluting stents: Part II.
Preclinical Data Unlike other antimitotic agents, paclitaxel shifts the cytoskeleton equilibrium toward assembly, leading to reduced vascular cell proliferation, migration, and signal transduction.2 Paclitaxel is highly lipophilic, resulting in a rapid cellular uptake and a long-lasting effect in the cell.3 NIR stents (Boston Scientific Corp) coated with poly(lactide-co-caprolactone) copolymer ...
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The ‘traditional’ view of drug discovery involves a linear process of identifying and validating a target, generating a lead molecule, optimizing its properties and then proceeding to preclinical and clinical studies. In this scheme, the biologists take the lead in identifying and validating a target. The chemists subsequently look for potent smallmolecule inhibitors, most often through optimiz...
متن کاملNew frontiers in cardiology: drug-eluting stents: Part I.
Stents represent a major advance in the treatment of obstructive coronary artery disease since the advent of balloon angioplasty. The number of percutaneous coronary interventions performed each year has expanded considerably since the early days. Angioplasty procedures doubled in Europe between 1992 and 1996,1 while an estimated 601 000 percutaneous coronary revascularizations were performed i...
متن کاملProteomics: delivering new routes to drug discovery - Part 1.
USA) provided a broad coverage of the application of innovative proteomic technologies for drug discovery. It would be difficult to review the large number of presentations during the four days and details of technologies are described elsewhere 1. The first part of this conference review deals with the role of proteomics in drug development and structural genomics.scribed the company's protein...
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ژورنال
عنوان ژورنال: Future Medicinal Chemistry
سال: 2016
ISSN: 1756-8919,1756-8927
DOI: 10.4155/fmc-2000-003